This article systematically describes the principle of sphere sovereignty according to Abraham Kuyper. Four themes are critically examined: the sovereignty of Christ as the main basis of Kuyper’s principle and its relation to creation, fall, and redemption; structural pluralism as the way of understanding social structure; the notion of religious and confessional pluralism; finally, the role of the state as the sphere of spheres. A positive critique of Kuyper’s principle is given in conclusion.