This article examines and ethically assesses “transgenderism-arming” approaches to the phenomenon of gender dysphoria. It discusses major approaches, identified as “modern” and “postmodern.” These rely respectively on either scientific “evidence” or philosophical criticism. It examines the life experiences of transgender individuals, laying further foundations for an ethical evaluation from a Christian worldview. It shows that neither modern nor postmodern “trans-arming” approaches fit a Christian framework. Key biblical truths that speak to this issue include the binarity of sex and gender (synonymous in the biblical worldview), the unity of body and soul, the derivative nature of human identity, the need to extend truth and mercy to the suering, and the objective nature of truth in a revelational framework.