The French humanist Jacques Lefèvre d’Étaples (ca. 1460–1536) enjoyed in his lifetime a notoriety second only to Erasmus himself. His numerous works of biblical scholarship, his commentaries and homilies, and his translation of the Bible into French make him one of the most significant forerunners of the Reformation in Europe. His scholarly achievements as well as his profound piety deserve to be better known. While an in-depth study of Lefèvre’s scholarly achievements and theology is obviously not possible here, I propose to highlight his main contribution to biblical scholarship and hermeneutics.